After a lengthy renovation, XS Nightclub is set to reopen its doors at Wynn Las Vegas, and the venue has now confirmed exactly who will be behind the decks for the occasion. The celebration runs four nights, from Thursday, November 5 through Sunday, November 8, with a headliner lineup built almost entirely around artists who’ve spent years playing the room. It’s the first ground-up overhaul the club has gotten since it first opened on New Year’s Eve 2008, with programming shifted over to Encore Beach Club at Night during construction.
RÜFÜS DU SOL opens things with a DJ set on night one, and the timing makes it a genuinely rare booking. The trio has been telling fans their current run — which has already included four sold-out nights at Madison Square Garden, a headline slot at Wrigley Field, two nights at The Gorge, and a closing set at Outside Lands — is likely their last extended tour for a while, with the group planning to disappear into the studio once Austin City Limits wraps things up in October. This XS date won’t be the full live show with drummer James Hunt and the touring production rig, but a DJ set built around rare IDs and remixes rarely heard outside their own sets.
Friday, The Chainsmokers take over, marking a return for a duo with about as much history at XS as anyone. Alex Pall and Drew Taggart have held down Wynn Nightlife residencies for years, and this year saw them mark the tenth anniversary of Collage, the EP that turned “Closer” into a number-one hit and launched them from remix duo to pop mainstay. Their more recent work — Breathe and the Love Is Kind EP with Oaks — has pulled the project back toward club-focused sounds, making a room like XS a natural fit for where they’re at now. “We’ve had some of our favorite nights at XS over the years,” the duo said of the booking.
Saturday belongs to Calvin Harris, whose relationship with the venue dates back to 2011, when his first Las Vegas residency effectively set the template every other club in the city has followed since. After a stretch at Fontainebleau and a lighter 2025 touring schedule, Harris signed an exclusive two-year deal bringing him back to Wynn starting this January — meaning XS and Encore Beach Club are the only Las Vegas venues where he’ll perform through 2027. His most recent single, “Blessings” with Clementine Douglas, spent months on the Hot Dance/Electronic Songs chart. “I’ve played some incredible nights at XS, and it’s always been one of my favorite places to play in Las Vegas,” Harris said of the reopening.
The weekend closes Sunday with Diplo going back-to-back with HUGEL. Diplo has logged more sets at XS than almost anywhere else in his career, while Hugel brings the Latin house sound that’s carried his 2026 run from Ibiza to Coachella and his own XS dates this year. “Seeing XS evolve and take on a new identity is exciting, especially knowing how much the environment can influence the way the music connects with the crowd,” Hugel said. “I’m looking forward to experiencing the transformation firsthand.”
Specifics on the new design haven’t been shared publicly, though Wynn Nightlife has said the space will get updated interiors and new production technology while keeping the atmosphere that made the room a destination in the first place — a Roger Thomas-designed space built around a pool terrace with two-level cabanas and a booth built to play to both the indoor and outdoor crowds simultaneously. Adam Norotsky, VP of Wynn Nightlife, described the reopening as a chance to build on what XS has always stood for. “XS has always represented the intersection of exceptional entertainment, design, and hospitality, and this new era is an opportunity to build upon that legacy,” he said.
More names are expected to be added to the bill in the weeks ahead.
Tickets and VIP table information available here.
